Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Hec1/Nek2 - Nek2 inhibitor (R)-21

Nek2 inhibitor (R)-21

CAS No. 1364269-10-2

Nek2 inhibitor (R)-21( —— )

Catalog No. M11500 CAS No. 1364269-10-2

A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Nek2 inhibitor (R)-21
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM.
  • Description
    A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2; also shows >100-fold selectivity over a panel of 24 kinases; down-regulates C-Nap1 phosphoryation with IC50 of 0.8 uM, shows antiproliferative effect on U2OS, MDA-MB-231, HeLa and MCF7 cell with GI50 of 1.82, 4.16, 0.59 and 2.17 uM, respectively; is a valuable tool for investigating the role of Nek2 in the cell cycle and its function in mitotic organization.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Hec1/Nek2
  • Recptor
    Hec1/Nek2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1364269-10-2
  • Formula Weight
    490.545
  • Molecular Formula
    C24H25F3N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (R)-(Z)-4-(2-Amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-((5,5,5-trifluoropent-3-en-2-yl)oxy)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Innocenti P, et al. J Med Chem. 2012 Apr 12;55(7):3228-41.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Nek2 inhibitor 72

    A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM.

  • HCI-2389

    A potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.

  • INH-6

    A small molecule inhibitor of Nek2/Hec1 that inhibits cell growth of MB231, MB468, HeLa and K562 cells.

Sign In Join Free